No, you should not take Ibuprofen and then start a session of the Period Pain Relief Program. This makes it hard to determine what may be causing pain relief. So, when in pain, start with a session of the Period Pain Relief Program. Then you have two options. One, if you can, start another session of the Period Pain Relief Program. Two, if you cannot start another session, you may take 400mg of Ibuprofen. If the Ibuprofen doesn’t seem to work, start another session of the Period Pain Relief Program before taking more Ibuprofen.